Molecular and Psychological Determinants of Post-Surgical Recovery: Integrating Genetic, Biochemical, and Psychological Factors
DOI:
https://doi.org/10.59075/rjs.v3i1.75Keywords:
Post-surgical recovery, genetic polymorphisms, inflammatory markers, oxidative stress, psychological resilience, pain management.Abstract
Background: This involves a complex interaction of molecular, biochemical, and psychological factors for post-surgical recovery. It examines the relative contributions of genetic polymorphisms, inflammatory markers, oxidative stress, and psychological resilience to determining surgical outcomes. Methods: 120 postoperative patients were analyzed for genetic variations: IL-6 -174G>C and TNF-α rs1800629 (G>A); inflammatory markers IL-6, TNF-α, CRP; oxidative stress parameters MDA, SOD, GPx; and psychological status as indicated by the scores of HADS and CD-RISC. The pain intensity, healing time, and recovery in function were evaluated at the 30th postoperative day. Results: Patients with pro-inflammatory genetic polymorphisms showed higher IL-6 levels at 12.4 ± 2.3 pg/mL (p = 0.002) and delayed wound healing at 14.2 ± 3.5 days compared with 9.6 ± 2.8 days (p = 0.003). Oxidative stress markers expressed as MDA level were elevated at 3.6 ± 0.8 nmol/mL (p = 0.006) in patients who had high preoperative anxiety. Patients with psychological resilience had CD-RISC values >70, which translated to faster recovery at 8.9 ± 2.4 days (p = 0.005) and lower pain scores. Conclusion: The study emphasizes the interconnected role of genetic, biochemical, and psychological factors in recovery from surgery. A multidisciplinary approach including genetic screening, anti-inflammatory strategies, and psychological interventions can be beneficial for post-surgical outcomes. Personalized treatment programs should be developed to offer optimal care for the patient.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Research Journal of Psychology

This work is licensed under a Creative Commons Attribution 4.0 International License.